Friday, August 03, 2007

Archive: Methyl Hydroxy Nandrolone (MOHN)

My article for Methyl Hydroxy Nandrolone (M4OHN) was written for the same company that I wrote my Methyl Hydroxy Testosterone (M4OHT) article for. It was also written in 2004 in a period leading up to the banning of prohormones, when manufacturers were bringing out all sorts of new compounds that were either active steroids or precursors to them. Most all of them had never been tested and were able to be created due to the new found access to a book by Julius Vida, a scientist who synthesized every possible modification of male sex steroids and then published them in a book, entitled "Androgens and Anabolic Agents, Chemistry and Pharmacology", in 1969. Although the book had been long out of date, an individual finally was able to find a copy of it and scanned it, converted it into PDF format, and sold it. This, along with the availability of Chinese companies to synthesize almost anything requested, allowed supplement companies to sell steroids that were never manufactured or widely used - and hence, not scheduled - a legal loophole that is still exploited to this day. Although for some reason, both M4OHN and M4OHT were banned by California state law, they were not banned in any other state, and as such, they were manufactured and sold until finally banned by the Anabolic Steroid Control Act of 2004.

Hydroxy Nandrolone, like its counterpart, Hydroxy Testosterone, is a steroid which is quite obscure and not much is written about it in medical literature. Hydroxy Nandrolone was produced commercially in Italy under the name Steranabol. However, it was sold as an injectable product, as opposed to an oral one, with cypionate ester attached. It is chemically known as oxabolone.

Nandrolone is the base steroid of Hydroxy Nandrolone. Nandrolone deconate is a popular anabolic steroid, commonly known as Deca Durabolin. Deca is well known for being a strong anabolic compound, with fewer androgenic properties. This is due to the fact that nandrolone is missing a carbon atom at the 19 position, giving it overall more affinity for the androgen receptor than testosterone. [1] However, unlike Hydroxy Nandrolone, nandrolone can aromatize into estrogen, which is another factor involved in it's strong anabolic effects.

Like Hydroxy Testosterone, Hydroxy Nandrolone also has a hydroxyl group at the 4 position on the molecule. This makes it incapable of interacting with the aromatese and 5 alpha reductase enzymes. However, since regular nandrolone typically reduces into a much weaker androgen, DHN (dihydronandrolone) via 5AR, this would make Hydroxy Nandrolone more androgenic. In the body nandrolone reduces to DHN through the same pathway that testosterone reduces to DHT. But, in this case, DHN is weaker and less androgenic than DHT, which is responsible for most of testosterone's androgenic effects (acne, androgenic alopecia, prostate issues, etc). So, with Hydroxy Nandrolone, we are left with a more potent androgen since it cannot convert through the same pathway. [2]

When we look at the information on Steranabol, we see that it is overall less potent than its parent, nandrolone. [3] Although not structurally similar, Methyl Hydroxy Nandrolone is probably closer in action to another popular steroid, oxandrolone. Oxandrolone, commonly known for its trade name, Anavar, a very mild oral steroid, even though it's a 17-alpha-alkylated (methylated) compound that's based on DHT. Oxandrolone is well known for for it's safety and low potential for HTPA shutdown. It is usually incorporated into cutting or lean mass cycles, as it will not aromatize because of it's DHT base.

Because of it being derived from DHT, oxandrolone can be somewhat androgenic in higher doses, and this will probably not be as pronounced with Hydroxy Nandrolone. This is because the hydroxyl group reduces androgen receptor binding affinity. There is also a question of progesterone related activity with this compound. It is well known that nandrolone and its derivatives can bind to the progesterone receptor. [4] However, it is thought that progesterone requires the presence of estrogen in order to cause gyno. Therefore, those prone to gyno may not want to use Hydroxy Nandrolone with another aromatizing compound like 4AD, while others might simply just use an anti-estrogen, such as tamoxifen citrate (Nolvadex) - a SERM, or an AI like ATD while on a cycle. However, it is unknown what affinity Hydroxy Nandrolone has for the progesterone receptor, so taking precaution is not unwarranted.

With Methyl Hydroxy Nandrolone, or MOHN, we end up with a very interesting compound. Using MOHN, one would expect increases in lean muscle mass, as well as a noticeable increase in strength. Since MOHN doesn’t aromatize, you would not notice water retention, or other estrogenic side effects typically associated with Deca. MOHN would work well during bulking cycles with the addition of 4AD and 1-testosterone or 1,4andro, and probably work even better on cutting cycles with a lower dose of 4AD. MOHN should be well tolerated by people concerned about side effects, and even women. Being a methylated compound, it will increase strain on the liver, so it would be best not to stack it with other methylated substances. As with MOHT, supplements that assist in liver function, such as ALA, NAC and Milk Thistle would be a welcome addition to the stack.

1. Bergink EW, Janssen PS, Turpijn EW, van der Vies J. Comparison of the receptor binding properties of nandrolone and testosterone under in vitro and in vivo conditions. J Steroid Biochem 1985 Jun;22(6):831-6

2. Van Mol, Peter. Steranabol.

3. Llewellyn, William. Anabolics 2004. Molecular Nutrition, Jupiter FL, 2004.

4. Reel JR, Humphrey RR, Shih YH, Windsor BL, Sakowski R, Creger PL, Edgren RA. Competitive progesterone antagonists: receptor binding and biologic activity of testosterone and 19-nortestosterone derivatives. Fertil Steril. 1979 May;31(5):552-61.

Wednesday, August 01, 2007

Archive: Methyl Hydroxy Testosterone (MOHT)

My two articles on Methyl Hydroxy Testosterone (M4OHT) and Methyl Hydroxy Nandrolone (M4OHN) were written for a supplement manufacturer who was selling the two compounds. When these articles were written in 2004, both of these were brand new compounds on the then still legal prohormone market. Unfortunately, shortly after M4OHT was released, it was discovered it wasn't just illegal in California, but actually scheduled in the Steroid Control Act of 1990 and removed from the market before very many people had a chance to try it. A slightly weaker version of the non-methylated version was also sold encapsulated in oil and bound to an ester. Neither M4OHT or M4OHN are legally available as a supplement and were permanently scheduled with the passing of the Anabolic Steroid Control Act of 2004.

Hydroxy Testosterone is a relatively new steroid on the supplement scene. William Llewellyn of Molecular Nutrition first brought the compound to the sports world's attention when he discussed its discovery on a popular bodybuilding forum. However, Hydroxy Testosterone did not see the light of day for quite some time after it was initially discussed.

Hydroxy Testosterone is an active metabolite of the European anti-aromatese drug, Formestane (4-hydroxy androstenedione). It was also investigated by the pharmaceutical firm Searle during the steroid hayday of the middle of the last century. However, it was never marketed as an anabolic, probably because of their more potent discovery oxandrolone. Being that it was never produced by a pharmaceutical, and never being included in the Anabolic Steroid Control Act of 1990, it can be considered legal (for the time being at least) to sell as a dietary supplement. However, hydroxy testosterone and its counterpart hydroxy nandrolone are not legal to sell in California, where it is a scheduled drug.

Hydroxy Testosterone is similar to the obscure anabolic steroid, Clostebol (sold commercially as Megagrisevit Mono). Clostebol has been marketed in the past, in parts of Europe and Asia, where it is used as a transdermal and injectable preparation. Clostebol has a chloro group on the 4 position of the molecule, making it incapable of interacting with both the 5 alpha reductase and aromatese enzymes. [1] Hydroxy Testosterone shares this feature by having a hydroxyl group at the same 4 position, it is also incapable of forming DHT and estrogen. This makes it an ideal drug for individuals looking to avoid the common side effects associated with other steroid and prohormone products. Hydroxy Testosterone also has the very interesting feature of acting as a mild aromatese inhibitor and 5 alpha reductese inhibitor. This means that it would act in a similar, albeit weaker, fashion to both the anti-aromatese drug anastrozole and the 5-AR inhibitor finasteride. [2]

According to standard assays of potency, Hydroxy Testosterone shows to have an RBA (relative binding affinity) of 75. When compared to testosterone propionate, hydroxyl testosterone acetate was shown to be 0.65 times as anabolic and 0.25 times as androgenic by injection. [3] This would make it a very mild androgen in nature, and very easy for individuals who are concerned about common side effects of steroidal compounds. Since it does not convert to estrogen or DHT, it would not be an ideal drug for bulking or strength gains, but more suited for lean muscle gains or even fat reduction. Women would most likely tolerate this drug very well.

Now, there is a new version of Hydroxy Testosterone available, which has been methylated. Methylating a drug makes an alteration at the C17 position of the molecule, allowing it to avoid liver breakdown. Two drugs which are methylated are the well known and popular illegal steroids, Winstrol and Dianabol. Although Methyl Hydroxy Testosterone, or MOHT, is not anywhere near as potent as those two compounds, it does have the same methyl alteration, increasing bioavailability and changing the action of the drug in the body. Generally, methylating a compound decreases the binding affinity towards the androgen receptor, making it less potent overall. However, since it greatly increases the half life, bioavailability and has other possible mechanisms, such as decreasing SHBG binding affinity, it would most likely make MOHT more favorable to use.

When we look for comparable drugs known to athletes, only one other comes to mind. Oral Turnibol (OT) is an exotic steroid developed for secret use by East German athletes. Currently, only one known underground lab is known to make it, and it is questionable whether or not it is legitimate. Recently, a prohormone has been sold by various companies of Oral Turnibol labeled as them chemical 4-chloro-17a-methyl-1,4-diene-3,17 diol. It is currently being sold as the supplement Halovar, which converts directly to OT. Oral Turnibol was East Germany's answer to the androgenic structure of Dianabol. [4] With a structure very similar to Methyl Hydroxy Testosterone, with the exception of a hydroxyl group in place of Turnibol's 4-chloro group, it has the same attributes. Turnibol cannot aromatize or convert to DHT. We could generally expect a similar result with MOHT, seen as significant gains in lean mass and mild increases in strength, without the negative side effects of Dianabol. [5] A very interesting account of the use of Oral Turnibol by female swimmers in the former communist East Germany is detailed in the book Faust's Gold by Dr. Steven Ungerleider.

Methyl Hydroxy Testosterone would stack well with just about anything. For bulking, it would stack very well with 4AD and possibly an oralgel or transdermal form of 1-testosterone, 1AD or 1,4andro. For cutting, it would stack well with 1-testosterone or 5AA. In both cases it would work well to help keep the other side effects minimal, by decreasing overall DHT and estrogen, as well as causing a positive hardening effect on the muscle. It would be wise not to stack it with another methylated compound, such as MOHN or Methyl-1-Test for fear of elevating liver enzymes too greatly. For individuals concerned with protecting their liver, supplementing with Milk Thistle or N-Acetyl-L-Cysteine (NAC) would be wise option.

The dosage of MOHT would probably be in the range of 5-15mg daily. It would be advisable to start off at a low dosage to find out how well it's tolerated, and then work up to a higher dosage. MOHT would be best taken with a meal.

1. Van Mol, Peter. Megagrisevit Mono.

2. Davies JH, Shearer RJ, Rowlands MG, Poon GK, Houghton J, Jarman M, Dowsett M. Effects of 4-hydroxyandrost-4-ene-3,17-dione and its metabolites on 5 alpha-reductase activity and the androgen receptor. J Enzyme Inhib. 1992;6(2):141-7.

3. Vida, J.A. Androgens and Anabolic Agents, Chemistry and Pharmacology. Academic Press, Inc, New York, 77-91, 1969.

4. Montana, Nelson. Johnny, We Hardly Knew Ye. Testosterone Nation.

5. Llewellyn, William. Anabolics 2004. Molecular Nutrition, Jupiter FL, 2004.
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